Real-World Evidence Diabetes - Finland

Finnish Real-World Data about Diabetes

We are currently evaluating the differences in real-world data in Diabetes in a few countries, intrigued by this recent paper:

  • Bak, Jessica C. G., Erik H. Serné, Mark H. H. Kramer, Max Nieuwdorp, and Carianne L. Verheugt. “National Diabetes Registries: Do They Make a Difference?” Acta Diabetologica, August 8, 2020. https://doi.org/10.1007/s00592-020-01576-8.

We have been in contact with the registry the holders to understand more about the registry, who recommended this publication to understand the registry:

It is a rich data-set that has been developed by merging several data-sources to one data-set to enable research about the long-term effect of diabetes. It does not include any diabetes specific additional data collection.

Below is a list of the publications originated from the registry, based on the above article:

  1. Arima, R., A. Hautakoski, M. Marttila, M. Arffman, R. Sund, P. Ilanne-Parikka, J. Kangaskokko, M. Hinkula, U. Puistola, and E. Läärä. ‘Cause-Specific Mortality in Endometrioid Endometrial Cancer Patients with Type 2 Diabetes Using Metformin or Other Types of Antidiabetic Medication’. Gynecologic Oncology 147, no. 3 (December 2017): 678–83. https://doi.org/10.1016/j.ygyno.2017.10.014.
  2. Arima, Reetta, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Jenni Kangaskokko, et al. ‘Antidiabetic Medication, Statins and the Risk and Prognosis of Non-Endometrioid Endometrial Cancer in Women with Type 2 Diabetes’. Anticancer Research 38, no. 7 (July 2018): 4169–78. https://doi.org/10.21873/anticanres.12710.
  3. Arima, Reetta, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Jenni Kangaskokko, Esa Läärä, Ulla Puistola, and Marianne Hinkula. ‘Antidiabetic Medication, Statins and the Risk of Endometrioid Endometrial Cancer in Patients with Type 2 Diabetes’. Gynecologic Oncology 146, no. 3 (September 2017): 636–41. https://doi.org/10.1016/j.ygyno.2017.06.011.
  4. Carstensen, Bendix, Stephanie H Read, Søren Friis, Reijo Sund, Ilmo Keskimäki, Ann-Marie Svensson, Rickard Ljung, et al. ‘Cancer Incidence in Persons with Type 1 Diabetes: A Five-Country Study of 9,000 Cancers in Type 1 Diabetic Individuals’. Diabetologia 59 (2016): 980–88. https://doi.org/10.1007/s00125-016-3884-9.
  5. ‘Diabeetikoiden Akuuttien Sydäntapahtumien Ja Aivoinfarktien Ilmaantumisessa Suuria Alueellisia Eroja’. Accessed 12 October 2020. https://www.duodecimlehti.fi/duo15448.
  6. ‘Diabetics Still Have a High Mortality Rate Compared to the Rest of the Population’. Accessed 12 October 2020. https://translate.google.com/translate?hl=en&sl=fi&u=https://www.laakarilehti.fi/tieteessa/alkuperaistutkimukset/diabeetikoilla-yha-suuri-ylikuolleisuus-muuhun-vaestoon-verrattuna/&prev=search&pto=aue.
  7. Finne, Patrik, Per-Henrik Groop, Martti Arffman, Marjo Kervinen, Jaakko Helve, Carola Grönhagen-Riska, and Reijo Sund. ‘Cumulative Risk of End-Stage Renal Disease Among Patients With Type 2 Diabetes: A Nationwide Inception Cohort Study’. Diabetes Care 42, no. 4 (April 2019): 539–44. https://doi.org/10.2337/dc18-1485.
  8. Forssas, E., K. Manderbacka, M. Arffman, and I. Keskimaki. ‘Socio-Economic Predictors of Mortality among Diabetic People’. The European Journal of Public Health 22, no. 3 (1 June 2012): 305–10. https://doi.org/10.1093/eurpub/ckr044.
  9. Forssas, Erja, Martti Arffman, Seppo Koskinen, Antti Reunanen, and Ilmo Keskimäki. ‘Socioeconomic Differences in Mortality among Diabetic People in Finland’. Scandinavian Journal of Public Health 38, no. 7 (1 November 2010): 691–98. https://doi.org/10.1177/1403494810376427.
  10. Forssas, Erja, Martti Arffman, Kristiina Manderbacka, Ilmo Keskimäki, Iiris Ruuth, and Reijo Sund. ‘Multiple Complications among People with Diabetes from Finland: An 18-Year Follow-up in 1994–2011’. BMJ Open Diabetes Research & Care 4, no. 1 (4 October 2016). https://doi.org/10.1136/bmjdrc-2016-000254.
  11. Forssas, Erja H., Ilmo T. Keskimäki, Antti R. Reunanen, and Seppo V. Koskinen. ‘Coronary Heart Disease among Diabetic and Nondiabetic People — Socioeconomic Differences in Incidence, Prognosis and Mortality’. Journal of Diabetes and Its Complications 22, no. 1 (1 January 2008): 10–17. https://doi.org/10.1016/j.jdiacomp.2007.05.004.
  12. Forssas, Erja, Reijo Sund, Kristiina Manderbacka, Martti Arffman, Pirjo Ilanne-Parikka, and Ilmo Keskimäki. ‘Increased Cancer Mortality in Diabetic People Treated with Insulin: A Register-Based Follow-up Study’. BMC Health Services Research 13 (9 July 2013): 267. https://doi.org/10.1186/1472-6963-13-267.
  13. Hakkarainen, Pirjo, Reijo Sund, Martti Arffman, Sari Koski, Vilma Hänninen, Leena Moilanen, and Kimmo Räsänen. ‘Working People with Type 1 Diabetes in the Finnish Population’. BMC Public Health 17 (12 October 2017). https://doi.org/10.1186/s12889-017-4723-8.
  14. Harjutsalo, Valma, Reijo Sund, Mikael Knip, and Per-Henrik Groop. ‘Incidence of Type 1 Diabetes in Finland’. JAMA 310, no. 4 (24 July 2013): 427. https://doi.org/10.1001/jama.2013.8399.
  15. Helve, Jaakko, Reijo Sund, Martti Arffman, Valma Harjutsalo, Per-Henrik Groop, Carola Grönhagen-Riska, and Patrik Finne. ‘Incidence of End-Stage Renal Disease in Patients With Type 1 Diabetes’. Diabetes Care 41, no. 3 (March 2018): 434–39. https://doi.org/10.2337/dc17-2364.
  16. Helve, Jaakko, Reijo Sund, Mikko Haapio, Per-Henrik Groop, Carola Grönhagen-Riska, and Patrik Finne. ‘Medication among Patients with Type 1 Diabetes and Predialytic Renal Disease’. Diabetes Research and Clinical Practice 103, no. 3 (March 2014): 510–15. https://doi.org/10.1016/j.diabres.2013.12.010.
  17. Hosio, Mayu, Elina Urpilainen, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Ulla Puistola, Esa Läärä, Arja Jukkola, and Peeter Karihtala. ‘Association of Antidiabetic Medication and Statins with Breast Cancer Incidence in Women with Type 2 Diabetes’. Breast Cancer Research and Treatment 175, no. 3 (June 2019): 741–48. https://doi.org/10.1007/s10549-019-05185-0.
  18. Ikonen, Tuija S., Reijo Sund, Maarit Venermo, and Klas Winell. ‘Fewer Major Amputations Among Individuals With Diabetes in Finland in 1997–2007’. Diabetes Care 33, no. 12 (December 2010): 2598–2603. https://doi.org/10.2337/dc10-0462.
  19. Kiivet, Raul, Reijo Sund, Miika Linna, Barbara Silverman, Heti Pisarev, and Nurit Friedman. ‘Methodological Challenges in International Performance Measurement Using Patient-Level Administrative Data’. Health Policy, Health System Performance Comparison: New Directions in Research and Policy, 112, no. 1 (1 September 2013): 110–21. https://doi.org/10.1016/j.healthpol.2013.05.011.
  20. ‘Kirjoitus (Sisältäen Ydinasiat,Tiivistelmät & Asiasanat)’, n.d.
  21. Manderbacka, K., M. Jokela, R. Sund, and M. Elovainio. ‘Treatment of Depression in Diagnosed Diabetes: Common Cause or Detection Bias?’ Psychological Medicine 44, no. 6 (April 2014): 1205–12. https://doi.org/10.1017/S0033291713001566.
  22. Manderbacka, Kristiina, Martti Arffman, Sonja Lumme, Markku Lehikoinen, Klas Winell, and Ilmo Keskimäki. ‘Regional Trends in Avoidable Hospitalisations Due to Complications among Population with Diabetes in Finland in 1996−2011: A Register-Based Cohort Study’. BMJ Open 6, no. 8 (22 August 2016). https://doi.org/10.1136/bmjopen-2016-011620.
  23. Manderbacka, Kristiina, Reijo Sund, Sari Koski, Ilmo Keskimäki, and Marko Elovainio. ‘Diabetes and Depression? Secular Trends in the Use of Antidepressants among Persons with Diabetes in Finland in 1997–2007’. Pharmacoepidemiology and Drug Safety 20, no. 4 (2011): 338–43. https://doi.org/10.1002/pds.2072.
  24. on behalf of the Scottish Diabetes Research Network Epidemiology Group and the Diabetes and Cancer Research Consortium, Daniel Levin, Samira Bell, Reijo Sund, Sirpa A. Hartikainen, Jaakko Tuomilehto, Eero Pukkala, et al. ‘Pioglitazone and Bladder Cancer Risk: A Multipopulation Pooled, Cumulative Exposure Analysis’. Diabetologia 58, no. 3 (March 2015): 493–504. https://doi.org/10.1007/s00125-014-3456-9.
  25. Ruokoniemi, Päivi, Reijo Sund, Martti Arffman, Arja Helin-Salmivaara, Risto Huupponen, Ilmo Keskimäki, Tuulikki Vehko, and Maarit Jaana Korhonen. ‘Are Statin Trials in Diabetes Representative of Real-World Diabetes Care: A Population-Based Study on Statin Initiators in Finland’. BMJ Open 4, no. 6 (18 June 2014). https://doi.org/10.1136/bmjopen-2014-005402.
  26. Saarela, Katri. ‘Cancer Incidence among Finnish People with Type 2 Diabetes during 1989–2014’, n.d., 7.
  27. Sund, Reijo, and D Soc. ‘Evaluation of Case Inclusion in Two Population‐based Diabetes Registers’. SCIENTIFIC PAPERS, n.d., 11.
  28. Urpilainen, E., M. Marttila, A. Hautakoski, M. Arffman, R. Sund, P. Ilanne‐Parikka, R. Arima, et al. ‘The Role of Metformin and Statins in the Incidence of Epithelial Ovarian Cancer in Type 2 Diabetes: A Cohort and Nested Case–Control Study’. BJOG: An International Journal of Obstetrics & Gynaecology 125, no. 8 (2018): 1001–8. https://doi.org/10.1111/1471-0528.15151.
  29. Urpilainen, Elina, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Reetta Arima, et al. ‘Prognosis of Ovarian Cancer in Women with Type 2 Diabetes Using Metformin and Other Forms of Antidiabetic Medication or Statins: A Retrospective Cohort Study’. BMC Cancer 18 (28 July 2018). https://doi.org/10.1186/s12885-018-4676-z.
  30. Vehko, Tuulikki, Kristiina Manderbacka, Martti Arffman, Antti Reunanen, and Ilmo Keskimäki. ‘Increasing Resources Effected Equity in Access to Revascularizations for Patients with Diabetes’. Scandinavian Cardiovascular Journal 44, no. 4 (August 2010): 237–44. https://doi.org/10.3109/14017431.2010.494309.
  31. Vehko, Tuulikki, Kristna Manderbacka, Martti Arffman, Reijo Sund, Antti Reunanen, and Ilmo Keskimäki. ‘Changing Patterns of Secondary Preventive Medication among Newly Diagnosed Coronary Heart Disease Patients with Diabetes in Finland: A Register-Based Study’. Scandinavian Journal of Public Health 38, no. 3 (1 May 2010): 317–24. https://doi.org/10.1177/1403494810364558.
  32. Vehko, Tuulikki, Reijo Sund, Martti Arffman, Kristiina Manderbacka, Pirjo Ilanne-Parikka, and Ilmo Keskimäki. ‘Monitoring the Use of Lipid-Lowering Medication among Persons with Newly Diagnosed Diabetes: A Nationwide Register-Based Study’. BMJ Open 3, no. 11 (4 November 2013). https://doi.org/10.1136/bmjopen-2013-003414.
  33. Vehko, Tuulikki, Reijo Sund, Kristiina Manderbacka, Unto Häkkinen, and Ilmo Keskimäki. ‘Pathways Leading to Coronary Revascularisation among Patients with Diabetes in Finland: A Longitudinal Register-Based Study’. BMC Health Services Research 11, no. 1 (3 August 2011): 180. https://doi.org/10.1186/1472-6963-11-180.
  34. Venermo, Maarit, Kristiina Manderbacka, Tuija Ikonen, Ilmo Keskimäki, Klas Winell, and Reijo Sund. ‘Amputations and Socioeconomic Position among Persons with Diabetes Mellitus, a Population-Based Register Study’. BMJ Open 3, no. 4 (1 January 2013): e002395. https://doi.org/10.1136/bmjopen-2012-002395.
  35. Winell, K. M., R. Pääkkönen, A. Pietilä, M. K. Niemi, A. R. Reunanen, and V. V. Salomaa. ‘Case Fatality Rates after First Acute Coronary Syndrome in Persons Treated for Type 2 Diabetes Show an Improving Trend’. Diabetologia 53, no. 3 (March 2010): 472–80. https://doi.org/10.1007/s00125-009-1606-2.
  36. Winell, K., M. Niemi, and M. Lepantalo. ‘The National Hospital Discharge Register Data on Lower Limb Amputations’. European Journal of Vascular and Endovascular Surgery 32, no. 1 (1 July 2006): 66–70. https://doi.org/10.1016/j.ejvs.2005.12.025.
  37. Winell, K., A. Pietilä, M. Niemi, A. Reunanen, and V. Salomaa. ‘Trends in Population Attributable Fraction of Acute Coronary Syndrome and Ischaemic Stroke Due to Diabetes in Finland’. Diabetologia 54, no. 11 (November 2011): 2789–94. https://doi.org/10.1007/s00125-011-2262-x.
  38. Winell, K., M. Venermo, T. Ikonen, and R. Sund. ‘Indicators for Comparing the Incidence of Diabetic Amputations: A Nationwide Population-Based Register Study’. European Journal of Vascular and Endovascular Surgery 46, no. 5 (1 November 2013): 569–74. https://doi.org/10.1016/j.ejvs.2013.07.010.
  39. Winell, Klas, Martti Arffman, Arto Pietilä, and Veikko Salomaa. ‘Regional Differences in the Incidence of Diabetic Cardiovascular Events Reflect the Quality of Care’. Scandinavian Cardiovascular Journal 52, no. 5 (3 September 2018): 232–37. https://doi.org/10.1080/14017431.2018.1497198.
  40. Winell, Klas, Rauni Pääkkönen, Arto Pietilä, Antti Reunanen, Marja Niemi, and Veikko Salomaa. ‘Prognosis of Ischaemic Stroke Is Improving Similarly in Patients with Type 2 Diabetes as in Nondiabetic Patients in Finland’. International Journal of Stroke 6, no. 4 (1 August 2011): 295–301. https://doi.org/10.1111/j.1747-4949.2010.00567.x.